Radiation-induced myofibroblastic sarcoma

Abstract

We report a clinical case about a male patient, smoker and alcoholic, that debuts with a neck metastasis of an epidermoid carcinoma of unknown origin. He was submitted to a cervical dissection and treated with adjuvant combined chemo and radio therapy. Four years after finishing the oncologic treatment without tumor recurrence or appearence of the primary tumor, he begins with sub acute dyspnea. After physical examination and imaging, a new larynx tumor was found, “low grade myofibroblastic sarcoma”. Under Cahan criteria, this tumoral kind, rare in larynx, was probably induced by the local ra- diotherapy. We discuss briefly the causality between radiation and oncogenesis and the characteristics of the radio induced tumors.