Nasosinusal Rosai-Dorfman disease: update on a case of progressive nasal obstruction

Abstract

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphade- nopathy, is a rare pathology, with a classic clinical presentation of painless bilateral massive cervical lymphadenopathy. The extranodal manifestations may involve skin, central ner- vous system, hematological, bones, and airway compromise, among others. Its diagnosis is challenging and requires a complete evaluation of the patient including medical history, physical examination, laboratory testing, imaging and histopathological study to confirm the diagnosis. Treatment should be individualized for each patient, including follow-up, systemic corticosteroids, radiotherapy, chemotherapy, immunomodulators and surgery. We present the case of a 65-year-old patient with a history of RDD located in the lacrimal glands and lymphoma, which begins with progressive bilateral obstruction refractory to me­dical treatment, for which it is decided to perform surgery, whose histopathological study confirmed RDD.